We are using cookies to implement functions like login, shopping cart or language selection for this website. Furthermore we use Google Analytics to create anonymized statistical reports of the usage which creates Cookies too. You will find more information in our privacy policy.
OK, I agree I do not want Google Analytics-Cookies
PERIO - Periodontal Practice Today
PERIO - Periodontal Practice Today 5 (2008), No. 1     3. Apr. 2008
PERIO - Periodontal Practice Today 5 (2008), No. 1  (03.04.2008)

Page 45-50

Ten-year results after treatment of intrabony defects with an enamel protein derivative (Emdogain)
Sculean, Anton / Kiss, Alice / Miliauskaite, Asta / Arweiler, Nicole Birgit / Hannig, Matthias / Schwarz, Frank
Treatment of intrabony periodontal defects with an enamel matrix derivative (EMD) promotes peri-odontal regeneration, i.e. regeneration of cementum, desmodontium and bone, resulting in significantreduction of probing depth and also in clinical attachment gain. There is, however, at present only lim-ited information available on long-term results of this regenerative form of therapy. The aim of thepresent study was to evaluate clinical results 10 years after treatment of intrabony defects with theenamel matrix derivative Emdogain®(Straumann, BaseI, Switzerland). Twenty-one patients who eachhad one intrabony defect with a probing depth >=6 mm were treated with enamel matrix proteins. Thefollowing clinical parameters were investigated before treatment as well as 1 year and 10 years aftertreatment: probing depth (PD), gingival recession (GR) and clinical attachment level (CAL). After oneyear, the average probing depth PD had been reduced from 8.1 ±1.7 mm to 3.5 ±1.0 mm (p < 0.0001). After 10 years, PD was 4.0 ±1.2 mm, i.e. significantly increased in comparison with the1-year results (p > 0.05). Compared with baseline there was, however, still a significant improvementin probing depth (p < 0.0001). After 1 year, GR had increased from 1.9 ±1.5 mm to 3.2 ±1.9 mm (p < 0.001). After ten years, GR was 2.8 ±1.5 mm. At this point in time, GR showed significant im-provement compared with the 1-year results, but was still significantly greater than at baseline (p < 0.001). Average CAL changed from 10.0 ±2.3 mm to 6.8 ±2.3 mm (p < 0.0001) after 1 year,and subsequently to 7.0 ±1.9 mm after 10 years. The change in CAL between 1 and 10 years was notstatistically significant. The results suggest that clinical improvements that have been achieved aftertreatment with enamel matrix proteins can be maintained over a period of 10 years.

Keywords: enamel matrix proteins, intrabony defects, long-term results, regenerative periodontal therapy