One statement holds true for all meta-analyses of regenerative periodontal therapy: the results show a marked heterogeneity, i.e. the results of regenerative therapy vary widely. What is the reason for this? Is it left to chance whether flap surgery with regenerative procedures, such as guided tissue regeneration (GTR) or enamel matrix proteins (EMP), results in improved attachment gain or osseous filling? Or are there factors that influence therapeutic success? One thing is clear: before planning regenerative procedures, anti-infectious therapy should be completed. Patients should practice proper personal oral hygiene and, other than the defects that are to be regenerated, residual pockets should be absent. Other factors influencing the success of regenerative therapy in bony pockets and class II furcation defects are smoking, defect depth and breadth, availability of soft tissue for flap formation, position of the furcation fornix in relation to approximal bone, and tooth mobility.
Keywords: enamel matrix proteins (EMP), guided tissue regeneration (GTR), patient- and defect-related influencing factors, regenerative periodontal therapy