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PERIO - Periodontal Practice Today
PERIO - Periodontal Practice Today 3 (2006), No. 4     28. Nov. 2006
PERIO - Periodontal Practice Today 3 (2006), No. 4  (28.11.2006)

Page 295-303

Evaluation of Platelet-Rich Plasma in Combination with Deproteinized Bovine Bone Mineral in the Rabbit Cranium
Shayesteh, Yadollah Soleymani / Ardestani, Mohammad Amin Shafiee / Khorsand, Afshin / Motahhary, Pouria / Dehghan, Mohammad
Introduction: Reconstruction methods are an essential prerequisite for functional rehabilitation of the stomatognathic system. Platelet-rich plasma (PRP) offers a new and potentially useful adjunct to bone substitute materials in oral and maxillofacial reconstructive surgery. This animal study investigated the influence of PRP on the regeneration of bony defects, treated with deproteinized bovine bone mineral (DBBM).
Materials and Methods: Twenty New Zealand white rabbits were included in this randomised, blinded study. Three equal 3 x 6 mm cranial bone defects were created and immediately grafted with DBBM, PRP + DBBM, or no treatment as control. The defects were evaluated with histological and histomorphometric analysis performed at 2, 4, 8 and 12 weeks.
Results: The results showed a significant increase in histomorphometric bone area and trabecular maturity in both DBBM and DBBM + PRP samples as compared with the control after 4, 8 and 12 weeks. A significant increase in bone formation was seen with the addition of PRP to DBBM after 2, 4 and 8 weeks. At 12 weeks, the level of bone formation had adjusted similarly between the two groups. There was also a significant increase in the rate of biodegradation of DBBM particles after the addition of PRP throughout the study period. Neither foreign body reaction nor severe inflammation was seen in any of the specimens evaluated.
Conclusions: Under the limitations of this study, PRP added additional benefits when DBBM was used in rabbit cranial defects concerning the speed of bone regeneration and the rate of biomaterial degradation.

Keywords: animal study, bone grafting, deproteinized bovine bone mineral, histomorphometry, platelet-rich plasma