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PERIO - Periodontal Practice Today
PERIO - Periodontal Practice Today 3 (2006), No. 2     15. June 2006
PERIO - Periodontal Practice Today 3 (2006), No. 2  (15.06.2006)

Page 105-113

Bioactive Glass with or without Enamel Matrix Derivative in Class II Furcation Lesions: Histomorphometric Study in Dogs
Pontes, Ana Emília F./Palioto, Daniela B./Novaes Jr, Arthur B./Souza, Sérgio L. S./Taba Jr, Mário/Grisi, Márcio F. M.
Background: The aim of this study was to evaluate the influence of bioactive glass (BG), with or without enamel matrix derivative (EMD) in the treatment of class II furcation lesions.
Methods: Experimental furcation defects were surgically created on mandibular P2, P3 and P4 of 6 mongrel dogs, and filled with gutta-percha. Four weeks later, the defects were debrided, the roots were planed and notches were placed at bone level. Each tooth was randomly assigned into BG+EMD, BG or internal control group. The animals were sacrificed 12 weeks later.
Results: The results for the groups control, BG and EMD+BG were, respectively: extension of new cementum (ENC), 49.55 ± 15.43%, 84.01 ± 7.87%, 91.96 ± 5.69%; epithelium extension (EE), 27.00 ± 23.89%, 4.79 ± 6.98%, 1.89 ± 2.47%; extension of connective tissue (ECT), 23.44 ± 9.09%, 11.20 ± 4.87%, 6.15 ± 5.19%; bone fill area (BFA), 51.15 ± 9.23%, 74.97 ± 9.02%, 76.53 ± 4.48%; mineralised bone (MB), 40.15 ± 9.95%, 31.65 ± 15.61%, 37.64 ± 16.25%; and bone marrow (BM), 11.00 ± 3.91%, 32.05 ± 14.61%, 31.13 ± 15.25%. The area of residual bioactive glass particles in the BG group was 11.28 ± 6.81%, and in the BG+EMD group was 7.76 ± 3.14%. No statistical differences (p > 0.05) were observed in any parameter between BG and BG+EMD groups, and between BG and internal control. However, comparing the BG+EMD group with the internal control group, statistically significant differences were observed concerning ENC and ECT (p < 0.05).
Conclusion: Within the limits of the present study, it can be concluded that BG and BG+EMD have the potential to improve periodontal regeneration, and that the association seems to favour the cementum formation.

Keywords: enamel matrix derivative, bioactive glass, furcation lesions, dog, periodontal regeneration