PERIO - Periodontal Practice Today
PERIO - Periodontal Practice Today 5 (2008), No. 4     4. June 2009
PERIO - Periodontal Practice Today 1 (2004), No. 4  (12.01.2005)

Page 321-325


Effect of Systemically Administered Azithromycin in Early Onset Aggressive Periodontitis
Fujii, Takeo/Wang, Pao-Li/Hosokawa, Yoichiro/Shirai, Shinichi/Tamura, Atsumu/Hikita, Kazuhiro/Maida, Takeo/Ochi, Morio/Baehni, Pierre C.
Azithromycin is a macrolide which possesses a strong antimicrobial activity against Gram-positive and Gram-negative pathogens. In the present study, we studied the effect of azithromycin as an adjunct to non-surgical treatment in early onset aggressive periodontitis. Initial treatment consisting of oral instructions and full-mouth scaling and root planing was performed over a 2-month period. Patients were then administered with azithromycin, 500 mg per os, 1x/day, for 3 days. Professional mechanical tooth cleaning was performed once every two weeks during the initial preparation. Initial treatment was considered as completed when the gingival index was < 1. The probing pocket depth, percentage of periodontal pockets with depth >= 4 mm, and the rate of bleeding on probing improved following treatment. The duration of the treatment was 4.7 ± 3.2 months. Another group of patients received the same initial treatment but without azithromycin. The duration of the treatment for this group was 11.2 ± 4.9 months. These results indicate that azithromycin may be useful for the treatment of early onset periodontitis.

Keywords: azithromycin, early onset periodontitis, systemic administration