This case report demonstrates minimal invasive regenerative therapy using enamel matrix derivative in a patient with chronic periodontitis. The microsurgical approach using a modified and simplified papilla preservation technique in an intraalveolar 2-wall bony defect was effective in the regeneration of periodontal soft and hard tissues. The minimal-invasive technique enabled primary wound healing with minimal recession and considerable attachment gain after 6 months.

Keywords: chronic periodontitis, regenerative therapy, Emdogain Gel‰, infrabony defects, minimum invasive surgery, modified papilla preservation flap, simplified papilla preservation flap, early healing index (EHI), primary healing