PERIO - Periodontal Practice Today
PERIO - Periodontal Practice Today 5 (2008), No. 4     4. June 2009
PERIO - Periodontal Practice Today 1 (2004), No. 2  (07.07.2004)

Page 97-109


Biomaterials for the Reconstructive Treatment of Periodontal Intrabony Defects.
Part II. Guided Tissue Regeneration, Biological Agents and Combination Therapies
Sculean, Anton/Jepsen, Søren
The aim of this paper is to present a critical overview, with emphasis on the evidence from human histology, on guided tissue regeneration, different types of biological agents and various combinations used in regenerative periodontal therapy of intraosseous defects. The available evidence indicates that surgical periodontal therapy employing the use of guided tissue regeneration, enamel matrix proteins or growth factors may result in periodontal regeneration. However, it is yet unknown to what extent a combination of guided tissue regeneration, enamel matrix proteins, growth factors and various types of bone grafts or bone substitutes may provide additional histological and clinical benefit.

Keywords: periodontal regeneration, human histology, controlled clinical studies, guided tissue regeneration, enamel matrix proteins, growth factors, review