PERIO - Periodontal Practice Today 5 (2008), No. 4 4. June 2009
PERIO - Periodontal Practice Today 5 (2008), No. 1 (03.04.2008)
Is there an association between periodontal disease and acute myocardial infarction? A cross-sectional study
Vijayalakshmi, Rajaram / Ramakrishnan, Thyagarajan / Ambalavanan, Namachivayam / Emmadi, Pamela / Saravanakumar, Ravindran / Anitha, Vijayarangan / Bhavana, Janardhanan
Aim:The aim of the present study was to investigate the association between periodontal disease andacute myocardial infarction (AMI).
Study design: A total number of 120 patients were selected for the study. Sixty patients who were ex-amined immediately following an episode of myocardial infarction were selected as the test group and60 patients suffering from chronic coronary heart disease were selected as the control group for thestudy. The study was conducted with the help of a medical history, periodontal examination and analy-sis of enzyme profile of the patient.
Results:Results of multiple logistic regression analysis, without adjusting for confounding factors,showed that plaque index (PI) >=2, periodontal disease index (PDI) >=4 and low density lipoproteinswere associated with AMI. Former smokers showed a significantly lower risk for AMI. After adjustingfor age, current smoking, diabetes, hypertension, low density lipoproteins and high density lipopro-teins, the results showed that PI >=2 and PDI >=4 were not significantly associated with AMI.
Conclusion:PI>=2 and PDI >=4 showed a significantly positive association with AMI, when the con-founding factors were not adjusted. However, once the confounding factors were adjusted, PI >=2 andPDI>=4 showed no association. This shows that risk factors such as smoking and hyperlipidemia havea more profound association with AMI than periodontal disease.
Keywords: association, confounding factors, lipids, periodontitis