PERIO - Periodontal Practice Today 5 (2008), No. 4 4. June 2009
PERIO - Periodontal Practice Today 5 (2008), No. 1 (03.04.2008)
Ten-year results after treatment of intrabony defects with an enamel protein derivative (Emdogain)
Sculean, Anton / Kiss, Alice / Miliauskaite, Asta / Arweiler, Nicole Birgit / Hannig, Matthias / Schwarz, Frank
Treatment of intrabony periodontal defects with an enamel matrix derivative (EMD) promotes peri-odontal regeneration, i.e. regeneration of cementum, desmodontium and bone, resulting in significantreduction of probing depth and also in clinical attachment gain. There is, however, at present only lim-ited information available on long-term results of this regenerative form of therapy. The aim of thepresent study was to evaluate clinical results 10 years after treatment of intrabony defects with theenamel matrix derivative Emdogain®(Straumann, BaseI, Switzerland). Twenty-one patients who eachhad one intrabony defect with a probing depth >=6 mm were treated with enamel matrix proteins. Thefollowing clinical parameters were investigated before treatment as well as 1 year and 10 years aftertreatment: probing depth (PD), gingival recession (GR) and clinical attachment level (CAL). After oneyear, the average probing depth PD had been reduced from 8.1 ±1.7 mm to 3.5 ±1.0 mm (p < 0.0001). After 10 years, PD was 4.0 ±1.2 mm, i.e. significantly increased in comparison with the1-year results (p > 0.05). Compared with baseline there was, however, still a significant improvementin probing depth (p < 0.0001). After 1 year, GR had increased from 1.9 ±1.5 mm to 3.2 ±1.9 mm (p < 0.001). After ten years, GR was 2.8 ±1.5 mm. At this point in time, GR showed significant im-provement compared with the 1-year results, but was still significantly greater than at baseline (p < 0.001). Average CAL changed from 10.0 ±2.3 mm to 6.8 ±2.3 mm (p < 0.0001) after 1 year,and subsequently to 7.0 ±1.9 mm after 10 years. The change in CAL between 1 and 10 years was notstatistically significant. The results suggest that clinical improvements that have been achieved aftertreatment with enamel matrix proteins can be maintained over a period of 10 years.
Keywords: enamel matrix proteins, intrabony defects, long-term results, regenerative periodontal therapy