PERIO - Periodontal Practice Today
PERIO - Periodontal Practice Today 5 (2008), No. 4     4. June 2009
PERIO - Periodontal Practice Today 4 (2007), No. 2  (13.06.2007)

Page 115-121


Role of curcumin as a subgingival irrigant: a pilot study
Suhag, Aparna / Dixit, Jaya / Dhan, Prakash
Background: The objective of this study was to evaluate subgingival irrigation as an adjunctive therapy and compare curcumin irrigation with commonly used irrigant chlorhexidine (0.2%).
Study design: Selected periodontal sites were treated on day 0 (baseline) by a single episode of scaling and root planing. Subsequently selected sites were irrigated (triple irrigation regimen) with either saline (0.9%), chlorhexidine (0.2%), curcumin (1%) or served as non-irrigated control sites on day 0 (baseline) immediately following instrumentation. Triple irrigation regimen was repeated for the next 5 consecutive days and on days 15 and 21. Clinical parameters recorded were probing pocket depth (PPD), bleeding on probing (BOP), and redness for 200 sites in 20 patients with chronic periodontitis. BOP and redness were recorded as dichotomous variables for 6 consecutive days and on days 15, 21 and 42; PPD was recorded on baseline and days 15, 21 and 42.
Results: Irrigated sites had significant improvement on all parameters as compared with nonirrigated sites on days 2, 3, 4 and 5. Curcumin group showed significant reduction in BOP (100%) and redness (96%) when compared with chlorhexidine group and saline group on day 5. However, the difference between groups was not significant at the next recall visits. Mean PPD reduction was significantly greater for the curcumin group than all other groups on all posttreatment days.
Conclusion: Subgingival irrigation is a useful adjunct and 1% curcumin solution is able to cause better resolution of inflammatory signs (BOP and redness) and PPD reduction than chlorhexidine and saline irrigation as an adjunctive therapy. However, further studies are required to substantiate these findings.

Keywords: chlorhexidine, curcumin, periodontitis, subgingival irrigation