PERIO - Periodontal Practice Today 5 (2008), No. 4 4. June 2009
PERIO - Periodontal Practice Today 3 (2006), No. 1 (16.03.2006)
The Evaluation of Clinical Parameters and Gingival Crevicular Fluid Prostaglandin E2 Level in Postmenopausal Females: A Pilot Study
Zeren, Cansu Basegmez/Yalcin, Funda/Issever, Halim/Isik, Gulden/Cekici, Ali/Onan, Utku
The purpose of this study was to evaluate the effects of postmenopausal alterations on clinical measurements and to assess the relationship between prostaglandine E2 (PGE2) level and clinical parameters after the menopause. Thirty-five postmenopausal women and 35 women who menstruated were selected. Plaque index (PI), gingival index (GI), probing pocket depth (PPD) and clinical attachment level (CAL) were measured. Gingival crevicular fluid PGE2 level was determined using the enzyme immunoassay technique. The statistical tests used were Student t-test and Pearson Correlation Analysis. In the test group, the levels of PGE2 and the mean values of GI, PPD and CAL were found to be significantly higher than in the controls, and the correlation between PGE2 level and PPD was found to be significant (p<0.05). It can be speculated that clinical parameters may be affected depending on the negative effects of the menopause, and PGE2 level may increase directly with increasing probing depth in this selected group of postmenopausal females.
Keywords: menopause, GCF PGE2 level, clinical parameters